miRNA Associated With Glucose Transporters in Oral Squamous Cell Carcinoma: A Systematic Review

Oral squamous cell carcinoma (OSCC) is a malignancy of the oral cavity with poor prognosis. Dysregulation in glycolytic pathways involving glucose transporters (GLUT) has been implicated Furthermore, GLUT expression cancer cells regulated by several miRNAs. However, there lack data about miRNA involved regulation OSCC. The objective to evaluate role Data sources include PubMed (MEDLINE), Scopus, and Web Science. Studies evaluating or associated OSCC were included systematic review. pertaining extracted from studies. Qualitative assessment was carried out for miRNA. Newcastle-Ottawa Scale used quality assessment. Ten study articles after analyzing 4675 papers. These studies evaluated between healthy samples. There are variable patterns it dependent on GLUT1 GLUT-3 detected more frequently OSCC, while no reveals GLUT2, GLUT4, GLUT7, GLUT8, GLUT13, SGLT1, SGLT2 regulation. insufficient evidence specific linked GLUT3 expression. especially OSCC; however, relation understudied. In future, exploring clearer understanding association metabolic pathway warranted. progression disease, disease resistance, prognosis assessed better treatment outcomes.